Mikulov and its surroundings is a traditional wine centre. The geographical position, the climate and the varied soil of the Mikulov wine region with the limestone slopes of the Pálava Hills affect the unique character of the local wine. This was already discovered by Ancient Romans, who considered the Pálava region ideal for vine growing.

The major wine centres of the Mikulov wine region include Mikulov in the first place, and further Valtice, Dolní Dunajovice, Novosedly, Perná, Sedlec, Pavlov, Dolní Věstonice, Horní Věstonice and Brod nad Dyjí.